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BioViotica
Bafilomycin C1
180
CHF
CHF 180.00
In stock
BVT-0068-M0011 mgCHF 180.00
| Product Details | |
|---|---|
| Synonyms | L-681,110A1; 2-Demethyl-2-methoxy-24-methyl-hygrolidin |
| Product Type | Chemical |
| Properties | |
| Formula |
C39H60O12 |
| MW | 720.9 |
| CAS | 88979-61-7 |
| Source/Host Chemicals | Isolated from Streptomyces sp. Gö 14F. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| Other Product Data |
May undergo transformation to methyl ketal on long term storage in methanol. We recommend the use of fresh solutions. |
| InChi Key | WUDBXVQNMOTFEE-WSNZTHDZSA-N |
| Smiles | [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C/[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)\C=C\C(O)=O)[C@H](C)[C@H](O1)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Specific vacuolar-type H+-ATPase inhibitor.
- Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
- Antibacterial, insecticidal and anthelmintic.
- Antifungal activity, especially against C. albicans.
- Potential anti-osteoporotic agent in treating bone lytic diseases.
- Neuroprotection inducer.
- Cytotoxic activity against SMMC7721 HCC cells.
- Potential candidate for hepatic carcinoma chemotherapy.
Product References
- Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984)
- Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993)
- Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
- Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) (Review)
- Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007)
- Low-dose Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. Pivtoraiko, et. al.; J. Neurochem. 114, 1193 (2010)
- Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption-implications for osteoclast quality: A. Neutzsky-Wulff, et. al.; BMC Musculoskel. Disord. 11, 1471 (2010)
- Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces: N. Ding, et al.; J. Nat. Prod., 79, 799 (2016)
- Bafilomycin C1 exert antifungal effect through disturbing sterol biosynthesis in Candida albicans: H. Su, et al.; J. Antibiot. 71, 467 (2018)
- Bafilomycin C1 induces G0/G1 cell-cycle arrest and mitochondrial-mediated apoptosis in human hepatocellular cancer SMMC7721 cells: X. Gao, et al.; J. Antibiot. 71, 808 (2018)
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