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BioViotica
Deoxynojirimycin
25
CHF
CHF 25.00
In stock
BVT-0112-M0011 mgCHF 25.00
BVT-0112-M0055 mgCHF 85.00
| Product Details | |
|---|---|
| Synonyms | 1,5-Dideoxy-1,5-imino-D-glucitol; Moranoline; DNJ |
| Product Type | Chemical |
| Properties | |
| Formula |
C6H13NO4 |
| MW | 163.2 |
| CAS | 19130-96-2 |
| RTECS | TN4350300 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (10mg/ml) or water (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | LXBIFEVIBLOUGU-JGWLITMVSA-N |
| Smiles | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Polyhydroxylated piperidine alkaloid.
- α-Glucosidase I and II inhibitor.
- Antidiabetic. Antihyperglycaemic activity.
- Glycosylceramidase inhibitor.
- Animal feedstuff additive.
- Antiviral. Shows anti-HIV activity.
Product References
- Isolation and structure of an unusual cyclic amino alditol from a legume: L.E. Fellows, et al.; Chem. Comm. 22, 977 (1979)
- Glucosidase inhibitors from Bacilli: D.D. Schmidt, et al.; Naturwissenschaften 66, 584 (1979)
- Glucosiddase inhibitors: structures of deoxynojirimycin and castanospermine: A. Hempel, et al.; J. Med. Chem. 36, 4082 (1993)
- Polyhydroxylated alkaloids - natural occurrence and therapeutic applications: A.A. Watson, et al.; Phytochem. 56, 265 (2001)
- Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses: J. Chang, et al.; Antiviral Research 98, 432 (2013)
- 1-deoxynojirimycin isolated from a bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes: S.-M. Lee, et al.; J. Microb. Biotechn. 23, 637 (2013)
- Novel imino sugar α-glucosidase inhibitors as antiviral compounds: J.D. Howe, et al.; Bioorg. & Med. Chem. 21, 4831 (2013)
- 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells: E., Shuang, et al.; Exp. Gerontol. 55, 63 (2014)
- 1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice: H. Do, et al.; Food Chem. Toxicol. 75, 1, (2015)
- 1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice: Q. Liu, et al.; Molecules 20, 21700 (2015)
- Iminosugars as immunomodulating agents: synthesis and biological activities of 1-deoxynojirimycin and related compounds: Q. Li & X.-S. Ye; Isr. J. Chem. 55, 336 (2015)
- Iminosugars: the potential of carbohydrate analogs: N. Asano; Carbohydr. Chem. 2016, 279 (2016)
- 1-Deoxynojirimycin alleviates liver injury and improves hepatic glucose metabolism in db/db mice: Q. Liu, et al.; Molecules 21, 279/1 (2016)
- 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing: K. Gao, et al.; Molecules 21, 1600 (2016) (Review)
- Protective mechanism of Rice-derived Lipids and Glucosylceramide in an In Vitro Intestinal Tract Model: S. Yamashita, et al.; J. Agric. Food Chem. 69, 10206 (2021)
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