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BioViotica
5-Hydroxymethylcytosine
130
CHF
CHF 130.00
In stock
BVT-0229-M01010 mgCHF 130.00
| Product Details | |
|---|---|
| Synonyms | 5hmC; Demethylbacimethrin |
| Product Type | Chemical |
| Properties | |
| Formula |
C5H7N3O2 |
| MW | 141.1 |
| CAS | 1123-95-1 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white powder. |
| Solubility | Soluble in water, DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | RYVNIFSIEDRLSJ-UHFFFAOYSA-N |
| Smiles | NC1=C(CO)C=NC(=O)N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Modified base of mammalian DNA.
- Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis.
- Important epigenetic marker.
- Related to bacimethrin (Prod. No. BVT-0226).
Product References
- 5-Hydroxymethylcytosine, the sixth base of the genome: M. Münzel, et al.; Angew. Chem. Int. Ed. 50, 6420 (2011) (Review)
- 5-Hydroxymethylcytosine-mediated DNA demethylation in stem cells and development: W. Sun; Stem Cells 23, 923 (2014) (Review)
- 5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer: L. Kroetze, et al.; Biochim. Biophys. Acta 144, 1855 (2015) (Review)
- 5-Hydroxymethylcytosine: a new player in brain disorders?: Y. Cheng, et al.; Exp. Neurol. 268, 3 (2015) (Review)
- 5-Hydroxymethylcytosine: in cancer: significance in diagnosis and therapy: A. Vasanthakumar & L. A. Godley; Cancer Genet. 208, 167 (2015) (Review)
- New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine: E. Moen, et al.; Immunol. Rev. 236, 36 (2015) (Review)
- Role of 5-hydroxymethylcytosine in neurodegeneration: S. I. Sherwani & H. A. Khan; Gene 570, 17 (2015) (Review)
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