Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
BioViotica
Concanamycin C (high purity)
95
CHF
CHF 95.00
In stock
BVT-0254-C02525 µgCHF 95.00
BVT-0254-C100100 µgCHF 205.00
BVT-0254-C500500 µgCHF 575.00
BVT-0254-M0011 mgCHF 815.00
| Product Details | |
|---|---|
| Synonyms | 4'-O-De(aminocarbonyl)concanamycin A |
| Product Type | Chemical |
| Properties | |
| Formula |
C45H74O13 |
| MW | 823.1 |
| CAS | 81552-34-3 |
| RTECS | GK6887000 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, methanol, chloroform or acetonitrile; insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | XKYYLWWOGLVPOR-PLWOKYFKSA-N |
| Smiles | [H][C@@]1(C[C@@H](O)[C@H](O)[C@@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](\C=C\C)[C@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@@]1([H])OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H](O)[C@H](CC)[C@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Vacuolar-type H+-ATPase inhibitor.
- Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
- Anti-osteoporotic.
- Antiviral.
- Immunosuppressive.
- Antifungal and anti-yeast.
Product References
- Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 35, 1618 (1982)
- Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984)
- Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993)
- Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem. 275, 167 (2000)
- Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry 40, 2816 (2001)
- Inhibitors of V-ATPase: old and new players: M. Huss, et al.; J. Exp. Biol. 212, 341 (2009)
Related Products
