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BioViotica
Decarestrictine D
110
CHF
CHF 110.00
In stock
BVT-0283-M0011 mgCHF 110.00
| Product Details | |
|---|---|
| Synonyms | Tuckolide; (4S,5S,8S,10R,E)-4,5,8-Trihydroxy-10-methyl-3,4,5,8,9,10-hexahydro-2H-oxecin-2-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H16O5 |
| MW | 216.2 |
| CAS | 127393-89-9 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, methanol or acetone. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | HWMMWMJBUOCCFZ-XYEXOTNWSA-N |
| Smiles | C[C@@H]1C[C@H](O)\C=C\[C@H](O)[C@@H](O)CC(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Hypolipidemic.
- Cholesterol biosynthesis inhibitor.
Product References
- Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporustuberaster: W.A. Ayer, et al.; J. Nat. Prod. 55, 649 (1992)
- Secondary metabolites by chemical screening. 8. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. I. Strain description, fermentation, isolation and properties: S. Grabley, et al.; J. Antibiot. (Tokyo) 45, 56 (1992)
- Secondary metabolites by chemical screening. 9. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. II. Structure elucidation of the decarestrictines A to D: A. Göhrt, et al.; J. Antibiot. (Tokyo) 45, 66 (1992)
- A non-enzymatic reaction in the late biosynthesis of the decarestrictine family: M. Mayer & R. Thiericke; J. Antibiot. (Tokyo) 46, 1372 (1993)
- Synthesis of Tuckolide, a New Cholesterol Biosynthesis Inhibitor: M.B. Andrus & T.L. Shih; J. Org. Chem. 61, 8780 (1996)
- An efficient total synthesis of decarestrictine D: P. Gupta, et al.; Eur. J. Org. Chem. 2008, 1195 (2008)
- Asymmetric synthesis of allylsilanes by the borylation of lithiated carbamates: formal total synthesis of (-)-decarestrictine D: M. Binanzer, et al.; Angew. Chem. Int. Ed. 49, 4264 (2010)
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