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BioViotica
Rugulosin
395
CHF
CHF 395.00
In stock
BVT-0444-M0055 mgCHF 395.00
| Product Details | |
|---|---|
| Synonyms | (+)-Rugulosin; NSC 160880; NSC 249990; Radicalisin |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H22O10 |
| MW | 542.5 |
| CAS | 23537-16-8 |
| RTECS | VM1610000 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, acetone, ethanol or methanol. |
| Identity | Determined by 1H-NMR, MS and optical rotation. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | QFDPVUTXKUGISP-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(C(O)=C1)C(=O)C1=C(O)[C@H]3C(O)C4C5C(O)[C@H](C(O)=C6C(=O)C7=C(O)C=C(C)C=C7C(=O)C356)C14C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light when in solution. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin.
- Antibiotic (Streptococcus, Corynebacterium, MRSA).
- Antiviral, HIV-1 integrase inhibitor.
- DNA replication, transcription and repair inhibitor (carcinogenic activity).
- RNA polymerase and ribonuclease H inhibitor.
- Insecticidal activity.
- Inhibitor of N-Hsp90.
Product References
- Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
- Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
- Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
- Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
- Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
- Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
- Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
- Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
- New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
- Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)
- Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera: R. Bara, et al.; J. Antibiot. 66, 491 (2013)
- Distribution of the foliar fungal endophyte Phialocephala scopiformis and its toxin in the crown of a mature white spruce tree as revealed by chemical and qPCR analyses: S. L. Frasz, et al.; Can. J. Forest Res. 44,1138 (2014)
- Comparison of cytotoxic extracts from fruiting bodies, infected insects and cultured mycelia of Cordyceps formosana: R.-L. Lu, et al.; Food Chem. 145, 1066 (2014)
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