Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
BioViotica
Cephalochromin
170
CHF
CHF 170.00
In stock
BVT-0440-M0011 mgCHF 170.00
BVT-0440-M0055 mgCHF 505.00
| Product Details | |
|---|---|
| Synonyms | Cefalochromin; NSC201419; NSC627953; Antibiotic Sch45752; 2,2',3,3'-Tetrahydro-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-9,9'-bi[4H-naphtho[2,3-b]pyran]-4,4'-dione |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H22O10 |
| MW | 518.5 |
| CAS | 25908-26-3 |
| Source/Host Chemicals | Isolated from Pseudoanguillospora sp. (strain 6577). |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Orange amorphous powder. |
| Solubility | Soluble in DMSO, methanol, acetone or dichloromethane. |
| Identity | Determined by 1H-NMR, MS and CD. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | FCPNXYHPAIZMNJ-UHFFFAOYSA-N |
| Smiles | CC1CC(=O)C2=C(O)C3=C(C=C2O1)C(=CC(O)=C3O)C1=C(O)C=C(O)C2=C1C=C1OC(C)CC(=O)C1=C2O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin. Bis(naphtha-γ-pyrone) derivative similar to chaetochromin and ustilaginoidin [1, 3].
- Antibiotic [1].
- Antibacterial, antifungal and anti-algal compound [1, 7].
- Antitumor and cytotoxic compound [2].
- Calmodulin-sensitive PDE activity inhibitor [4].
- Inhibits NO production by activated macrophages [5].
- Selective Fabl (bacterial enoyl-acyl carrier protein (ACP) reductase) inhibitor [6].
- Inducer of G0/G1 cell cycle arrest and apoptosis in human A549 cells [8].
Product References
- Cephalochromin, dihydroiso-ustilaginoidin A and iso-ustilaginoidin A from Verticillium sp. K-113: M. Matsumoto, et al.; J. Antibiot. 28, 602 (1975)
- Cytotoxicity and antitumor activities of fungal bis(naphtho-gamma-pyrone) derivatives: K. Koyama, et al.; J. Pharmacobiodyn. 11, 630 (1988)
- The impairing effect of chaetochromin A and related mycotoxins on mitochondrial respiration: K. Kawai, et al.; Mycotoxins 33, 31-5 (1991)
- Sch 45752, an inhibitor of calmodulin-sensitive cyclic nucleotide phosphodiesterase activity: V.R. Hedge, et al.; J. Antibiot. 46, 207 (1993)
- Inhibitory effects of fungal bis(naphtho-γ-pyrone) derivatives on nitric oxide production by a murine macrophage-like cell line, RAW 264.7, activated by lipopolysaccharide and interferon-γ.: R. Ishii, et al.; Biol. Pharm. Bull. 28, 786 (2005)
- Cephalochromin, a FabI-directed antibacterial of microbial origin: C.J. Zheng, et al.; BBRC 362, 1107 (2007)
- Pseudoanguillosporin A and B: two new isochromans isolated from the edophytic fungus Pseudoanguillospora sp.: I. Kock, et al.; Eur. J. Org. Chem. 2009, 1427 (2009)
- Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption: C.-J. Hsiao, et al.; J. Nat. Prod. 77, 758 (2014)
Related Products
