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BioViotica
Cytochalasin H
115
CHF
CHF 115.00
In stock
BVT-0447-M0011 mgCHF 115.00
| Product Details | |
|---|---|
| Synonyms | Paspalin P1; Kodocytochalasin 1; Cytochalasin O; NSC305222; 17-Deoxo-21-acetylzygosporin D |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H39NO5 |
| MW | 493.6 |
| CAS | 53760-19-3 |
| RTECS | HA5306000 |
| Source/Host Chemicals | Isolated from Phomopsis sp. |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, methanol or acetone. |
| Identity | Determined by 1H-NMR and 13C-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | NAEWXXDGBKTIMN-CGCBHLOZSA-N |
| Smiles | [H][C@]12[C@H](CC3=CC=CC=C3)NC(=O)[C@@]11[C@@H](\C=C\C[C@H](C)C[C@@](C)(O)\C=C\[C@H]1OC(C)=O)[C@H](O)C(=C)[C@H]2C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution protect from light at -20°C. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent mycotoxin.
- Phytotoxin.
- Actin polymerization inhibitor. Used in actin polymerization and cytoskeletal reorganization studies.
- Antibacterial, antifungal, nematocidal and antitumor compound.
- Apoptosis inducer.
- Anti-angiogenic agent.
- Shows immunosuppressive activity.
- Shown to modulate the CNS with potential anti-parkinson activity.
Product References
- Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.: J.M. Wells, et al.; Can. J. Microbiol. 22, 1137 (1976)
- Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1: M. A. Beno, et al.; JACS 99, 4123 (1977)
- Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells: S. Ghaskadbi & L. Mulherkar; Indian J. Exp. Biol. 20, 869 (1982)
- Effects of cytochalasin H on chick embryo explants cultured in vitro: S. Ghaskadbi, et al. Toxicology 33, 323 (1984)
- Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell Biol. 105, 1473 (1987)
- A new immunosuppressive cytochalasin isolated from a Pestalotia sp.: N. S. Burres, et al.; J. Antibiot. 45, 1367 (1992)
- Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganization, on platelet function: P. Natajaran, et al.; Platelets, 11, 467 (2000)
- 1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08): Y. Tao, et al.; Magn. Reson. Chem. 46, 501 (2008)
- Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa: S. Xu, et al.; Chem. Biodivers. 6, 739 (2009)
- Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines: S.M. Stoeger & K.H. Cowan; Cancer Chemother. Pharmacol. 63, 807 (2009)
- Application of cytochalasin compound cytochalasin H in manufacture of the medicine for resisting Parkinson's disease: L. Shet, et al.; CN103816149 A20140528 (2014) (Patent)
- Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis Thorns: J. Lee, et al.; Biol. Pharm. Bull. 37, 6 (2014)
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