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BioViotica
Bafilomycin D (high purity)
215
CHF
CHF 215.00
In stock
BVT-0475-M0011 mgCHF 215.00
| Product Details | |
|---|---|
| Synonyms | Tubamycin; Antibiotic 3D5 |
| Product Type | Chemical |
| Properties | |
| Formula |
C35H56O8 |
| MW | 604.8 |
| CAS | 98813-13-9 |
| Source/Host Chemicals | Semi-synthetic product formed from Bafilomycin B1. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white to yellow solid. |
| Solubility | Soluble in DMSO, 100% ethanol, methanol, acetone or dichloromethane. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | ZKOTUWJMGBWBEO-YXTSRGFTSA-N |
| Smiles | CO/C1=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@]([C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H](C)[C@H](O)C(C)C)=O)([H])OC1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Macrolide antibiotic. Bafilomycin derivative, in which the characteristic hemiketal portion has been opened.
- Potent and specific vacuolar-type H+-ATPase inhibitor (V-ATPase).
- Antiproliferative agent against selected human glioma cell lines.
- Cytoxic activity. Active against Gram-positive bacteria and plant pathogen fungi.
- Shows weak insecticidal and anti-nematodic activity.
Product References
- The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin: A. Kretschmer, et al.; Agric. Biol. Chem. 49, 2509 (1985)
- Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Droese, et al.; Biochem. 32, 3902 (1993)
- Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
- Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Droese & K. Altendorf; J. Exp. Biol. 200, 1 (1997)
- Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups: M. G. O'Shea, et al.; J. Antibiot. 50, 1073 (1997)
- Bafilomycins and odoriferous sesquiterpenoids from Streptomyces albolongus isolated from Elephas maximus feces: N. Ding, et al.; J. Nat. Prod. 79, 799 (2016)
- Bioactive bafilomycins and a new N -arylpyrazinone derivative from marine-derived Streptomyces sp. HZP-2216E: Z. Zhang, et al.; Planta Med. 83, 1405 (2017)
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