|Source/Host Chemicals||Isolated from fungus Phomopsis sp M4.|
|Purity Chemicals||>97% (1H-NMR, HPLC)|
|Appearance||Pale yellow solid.|
|Solubility||Soluble in DMSO, methanol or acetone. Insoluble in water.|
|Identity||Determined by 1H-NMR and MS.|
|Declaration||Manufactured by BioViotica.|
|Other Product Data||
Note: P. Boehler (2018) describe that Phomoxanthone A becomes unstable if dissolved in DMSO, and readily isomerizes into the essentially non-toxic compound dicerandrol C. We advise therefore to dissolve the compound in DMSO immediately before usage.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
|Handling Advice||Protect from light when in solution.|
|Use/Stability||Stable for at least 1 year after receipt when stored at +4°C.|
|Product Specification Sheet|
- Antibacterial against Gram-positive bacteria.
- Shows antimalarial and antitubercular activity.
- Anticancer compound. Cytotoxic against several cancer cell lines (pro-apoptotic activity).
- Active against plant pathogene fungi (e.g. P. oryza, Phyt. infestans).
- Activator of murine T lymphocytes, NK cells and macrophages.
- Mitochondrial toxin with a mode of action distinct from known electron transport chain (ETC) inhibitors, OXPHOS uncouplers and ionophores. Shows rapid inhibition of both ETC and ΔΨm, the release of mitochondrial Ca2+ and fission of the inner but not the outer mitochondrial membrane independent from the mitochondrial fission and fusion regulators DRP1 and OPA1.
- Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species: M. Isaka, et al.; J. Nat. Prod. 64, 1015 (2001)
- X-ray Structure Determination, Absolute Configuration and Biological Activity of Phomoxanthone A: B. Elsasser, et al.; Eur. J. Org. Chem. 2005, 4563 (2005)
- Anticancer compounds derived from fungal endophytes: their importance and future challenges: R.N. Kharwar, et al.; Nat. Prod. Rep. 28, 1208 (2011)
- Isolation of a phomoxanthone A derivative, a new metabolite of tetrahydroxanthone, from a Phomopsis sp. isolated from the mangrove, Rhizhhopora mucronata: Y. Shiono, et al.; Nat. Prod. Commun. 8, 1735 (2013)
- Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla: D. Rönsberg, et al.; J. Org. Chem. 78, 12409 (2013)
- The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane: P. Boehler, et al.; Cell Death Dis. 9, 286 (2018)