CHF 370.00
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BVT-0455-M0011 mgCHF 370.00
BVT-0455-MM252.5 mgCHF 740.00
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Product Details
Synonyms Antibiotic U 24544; Erizomycin; NSC 246134
Product Type Chemical
Formula C27H32N4O8
MW 540.6
CAS 18791-21-4
Source/Host Chemicals Isolated from Streptomyces sp.
Purity Chemicals ≥98% (1H-NMR, HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO, methanol, water, dichloromethane or acetone.
Identity Determined by 1H-NMR and MS.
Declaration Manufactured by BioViotica.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cyclodepsipeptide antibiotic. Unusual 12-membered macrocyclic depsipeptide comprises three unique subunits incorporating two substituted pyridines.
  • Potent antitubercular agent.
  • Inhibitor of NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis.
  • Shown to be active against isoniazid-resistant mycobacteria.
Product References
  1. A new antibiotic, pyridomycin: K. Maeda, et al.; J. Antibiot. (Tokyo) 6, 140 (1953)
  2. Structure of pyridomycin: G. Koyama, et al.; Tetrahedron Lett. 37, 3587 (1967)
  3. Chemistry of pyridomycin: H. Ogawara, et al.; Chem. Pharm. Bull. 16, 679 (1968)
  4. Synthetic studies of pyridomycin. V. Total synthesis of pyridomycin: M. Kinoshita, et al.; Tetrahedron Lett. 30, 7419 (1989)
  5. Identification and characterization of the pyridomycin biosynthetic gene cluster of streptomyces pyridomyceticus NRRL B-2517: T. Huang, et al.; J. Biol. Chem. 286, 20648 (2011)
  6. Towards a new tuberculosis drug: pyridomycin - nature's isoniazid: R. C. Hartkoorn, et al.; EMBO Mol. Medicine 4, 1032 (2012)
  7. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA: R. C. Hartkoorn, et al.; Nat. Chem. Biol. 10, 96 (2014)
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