6-(4-Acetamido-1,8-naphthalamido) hexanoic acid

Specifications / Handling

More Information
Product Details
Product Type	Chemical
Properties
Formula	C₂₀H₂₀N₂O₅
MW	368.38
CAS	172227-59-7
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥95% (HPCE)
Appearance	Solid.
Solubility	Soluble in water or DMSO.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	RCZAYEHQRFPFSH-UHFFFAOYSA-N
Smiles	CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.

Product References

(1) K. Misra et al.; Radiobiol. Bio-Med. Res., 129 (2004) | (2) R.W. Odd et al.; Blackwell Scientific Publication, 317 (1992) | (3) R.J. Kaiser et al.; Nucleic Acids Research 17, 6087 (1989)

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