Chemodex

Actinomycin D

CHF 199.00

In stock

CDX-A0043-M02020 mgCHF 199.00

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Product Details
Synonyms	2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide
Product Type	Chemical
Properties
Formula	C₆₂H₈₆N₁₂O₁₆
MW	1255.42
CAS	50-76-0
Purity Chemicals	≥95% (HPLC)
Appearance	Red to orange solid.
Solubility	Soluble in acetone or methanol.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	ZOWMRHVAQGTFTG-IZRKADTCSA-N
Smiles	CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.

Product References

(1) H. Li et al., Bioorg. Med. Chem. 14(12), 4089 (2006) | (2) C. Liu et al.; Biochem. 35(50), 16346 (1996) | (3) J.A. Neidhart et al.; Cancer Treatment Reports 64(4-5), 553 (1980)

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