7-Azido-4-methylcoumarin

CHF 51.00
In stock
CDX-A0069-M0011 mgCHF 51.00
CDX-A0069-M01010 mgCHF 125.00
CDX-A0069-M05050 mgCHF 523.00
More Information
Product Details
Synonyms 7-Azido-4-methyl-1-benzopyran-2-one; AzMC
Product Type Chemical
Properties
Formula

C10H7N3O2

MW 201.18
CAS 95633-27-5
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance Yellow powder.
Solubility Soluble in DMSO.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key HEKDKVLIMUWRRZ-UHFFFAOYSA-N
Smiles CC1=CC(=O)OC2=CC(=CC=C12)N=[N+]=[N-]
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with λex = 365 nm and λem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine β-synthase (CBS) inhibitors and activators.

Product References

(1) G. Chen, et al.; Protein Sci. 8, 2151 (1999) | (2) M.K. Thorson, et al.; Angew. Chem. Int. Ed. Engl. 52, 4641 (2013) | (3) B. Chen, et al.; Analyst. 138, 946 (2013)

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