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Chemodex
Adenine
81
CHF
CHF 81.00
In stock
CDX-A0083-G02525 gCHF 81.00
CDX-A0083-G100100 gCHF 244.00
| Product Details | |
|---|---|
| Synonyms | 6-Aminopurine; Vitamin B4 |
| Product Type | Chemical |
| Properties | |
| Formula |
C5H5N5 |
| MW | 135.13 |
| CAS | 73-24-5 |
| RTECS | AU6125000 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble methanol or ethanol. Slightly soluble in water (~1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GFFGJBXGBJISGV-UHFFFAOYSA-N |
| Smiles | NC1=NC=NC2=C1N=CN2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP). Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
Product References
(1) G. Nuki; Ann. Rheum. Dis. 42, 8 (1983) | (2) R. Shapiro; Orig. Life Evol. Biosph. 25, 83 (1995) | (3) J. Ross; J. Phys. Chem. B 110, 6987 (2006) | (4) T.E. Parry; Leuk. Res. 31, 1621 (2007) | (5) D. Thimm, et al.; Acta Physiol. 213, 808 (2015) | (6) C. Wang, et al.; Acta Pharm. Sin. B. 5, 431 (2015)