Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
BAPTA tetrasodium salt
As low as
155
CHF
CHF 155.00
In stock
Only %1 left
CDX-A0119-G0011 gCHF 155.00
NEW
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | BAPTA tetrasodium salt; 1,2- bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic acid 4Na |
| Product Type | Chemical |
| Properties | |
| Formula | C22H20N2Na4O10 |
| MW | 564.36 |
| CAS | 126824-24-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to faint beige powder. |
| Solubility | Soluble in water (10 mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QEANQYJKLAFALF-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)c1ccccc1OCCOc2ccccc2N(CC([O-])=O)CC([O-])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light and oxygen. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
BAPTA is a membrane-impermeable highly selective calcium chelator and is useful for manipulating extracellular Ca2+ levels, with 10^5-fold greater affinity for Ca2+ than for Mg2+. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives can be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). Key advantages of BAPTA include relative insensitivity toward intracellular pH change and fast release of calcium. Its rapid calcium-binding kinetics and high affinity for Ca2+ make it an essential tool for studying calcium-dependent signaling pathways, enzyme activity, neurotransmitter release and other cellular processes.
Product-specific References
(1) R.Y. Tsien, et al.; Biochemistry. 19, 2396 (1980) | (2) R.Y. Tsien, et al.; Annu. Rev. Biophys. Bioeng. 12, 91 (1983) | (3) G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) | (4) H. Kijima, et al.; J. Physiol. 403, 135 (1988) | (5) N. Tanabe, et al.; Neurosci. Lett. 92, 52 (1988) | (6) R.C. Hardie; Cell Calcium. 38, 547 (2005) | (7) R.W. Sabnis; Handbook of biological dyes and stains (2010)