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Chemodex
Amorolfine hydrochloride
As low as
183
CHF
CHF 183.00
In stock
Only %1 left
CDX-A0301-M250250 mgCHF 183.00
CDX-A0301-M500500 mgCHF 305.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Amorolfin; (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H35ON . HCl |
| MW | 317.51 . 36.46 |
| CAS | 78613-38-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in ethanol (20mg/ml), DMSO (5mg/ml) or PBS, pH7.2 (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| Smiles | C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
Product-specific References
(1) T. Hiratani, et al.; Jpn. J. Antibiot. 44, 993 (1991) | (2) A. Polak; Dermatology 184, 3 (1992) | (3) M. Haria & H.M. Bryson; Drugs 49, 103 (1995) | (4) C. Flagothier, et al.; Mycoses 48, 91 (2005) (Review)