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Chemodex
Amorolfine hydrochloride
183
CHF
CHF 183.00
In stock
CDX-A0301-M250250 mgCHF 183.00
CDX-A0301-M500500 mgCHF 305.00
| Product Details | |
|---|---|
| Synonyms | Amorolfin; (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H35ON . HCl |
| MW | 317.51 . 36.46 |
| CAS | 78613-38-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in ethanol (20mg/ml), DMSO (5mg/ml) or PBS, pH7.2 (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| Smiles | C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
Product References
(1) T. Hiratani, et al.; Jpn. J. Antibiot. 44, 993 (1991) | (2) A. Polak; Dermatology 184, 3 (1992) | (3) M. Haria & H.M. Bryson; Drugs 49, 103 (1995) | (4) C. Flagothier, et al.; Mycoses 48, 91 (2005) (Review)