D-Aspartic acid

Specifications / Handling

More Information
Product Details
Synonyms	H-D-Asp-OH; D-Aspartate; D-Asp; (R)-(-)-Aminosuccinic acid; (R)-2-Aminosuccinic acid; D-Aminosuccinic acid
Product Type	Chemical
Properties
Formula	C₄H₇NO₄
MW	133.10
CAS	1783-96-6
Purity Chemicals	≥99% (Titration)
Appearance	White to off-white powder.
Solubility	Soluble in 1N ammonium hydroxide (100 mg/ml). Slightly soluble in water.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	CKLJMWTZIZZHCS-UWTATZPHSA-N
Smiles	O=C(O)[C@H](N)CC(O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at RT.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.

Product References

(1) H.J. Olverman, et al.; Neuroscience 26, 17 (1988) | (2) S. Ishio, et al; Neurosci. Lett. 249, 143 (1998) | (3) G. D'Aniello, et al.; Endocrinol. 141, 3862 (2000) | (4) A. D'Aniello; Brain Res. Rev. 53, 215 (2007) (Review) | (5) E. Topo, et al.; Reprod. Biol. Endocrinol. 7, 120 (2009) | (6) E. Topo, et al.; Amino Acids 38, 1561 (2010) | (7) S. D'Aniello, et al.; FASEB J. 25, 1014 (2011)

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