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Chemodex
3-Acetyl-11-keto-β-boswellic acid
162
CHF
CHF 162.00
In stock
CDX-A0327-M0055 mgCHF 162.00
| Product Details | |
|---|---|
| Synonyms | AKBA; AKβBA; 3-O-Acetyl-11-keto-β-boswellic acid |
| Product Type | Chemical |
| Properties | |
| Formula | C32H48O5 |
| MW | 512.72 |
| CAS | 67416-61-9 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in chloroform, methanol, DMSO (25mg/ml), DMF (25mg/ml) or ethanol (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HMMGKOVEOFBCAU-BCDBGHSCSA-N |
| Smiles | O=C1[C@@]([C@](CC2)(C)[C@@]([C@@](C)(C(O)=O)[C@@H]2OC(C)=O)([H])CC3)([H])[C@]3(C)[C@@]4(C)C([C@@]([C@@H](C)[C@H](C)CC5)([H])[C@@]5(C)CC4)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
3-Acetyl-11-keto-β-boswellic acid (AKBA) antitumor and anti-inflammatory activities. It is a potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. It exhibits in vivo efficacy in tumor growth inhibition and has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
Product References
(1) H. Safayhi, et al.; J. Pharmacol. Exp. Ther. 261, 1143 (1992) | (2) R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther. 288, 613 (1999) | (3) A. Altmann, et al.; BBRC 290, 185 (2002) | (4) A. Altmann, et al.; Br. J. Pharmacol. 141, 223 (2004) | (5) T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) | (6) L. Xia, et al.; Mol. Cancer Therap. 4, 381 (2005) | (7) M. Bishnoi, et al.; Indian J. Exp. Biol. 44, 128 (2006) | (8) C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) | (9) D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006) (Review)