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Chemodex
Ascorbic acid 6-palmitate
48
CHF
CHF 48.00
In stock
CDX-A0534-G02525 gCHF 48.00
CDX-A0534-G100100 gCHF 108.00
| Product Details | |
|---|---|
| Synonyms | AA6P; 6-O-Palmitoyl-L-ascorbic acid; Ascorbylpalmitic Acid; L-Ascorbic acid 6-hexadecanoate; L-Ascorbyl palmitate; Ascorbic acid 6-palmitate; NSC 402451 |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H38O7 |
| MW | 414.53 |
| CAS | 137-66-6 |
| Purity Chemicals | ≥95% |
| Appearance | Light yellow powder. |
| Solubility | Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QAQJMLQRFWZOBN-UWJYYQICSA-N |
| Smiles | OC1=C(O)C(O[C@@]1([H])[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.
Product References
(1) W.M. Cort; J. Am. Oil Chem. Soc. 51, 321 (1974) | (2) R.C. Smart & C.L. Crawford; Am. J. Clin. Nutr. 54, 1266S (1991) | (3) H. Chen & A.L. Tappel; Free Radic. Res. 22, 177 (1995) | (4) N. Perricone, et al.; BBRC 262, 661 (1999) | (5) O. Yilmaz, et al.; J. Cell Biochem. 86, 530 (2002) | (6) A. Meves, et al.; J. Invest. Dermatol. 119, 1103 (2002) | (7) K.M. Lee, et al.; Mutat. Res. 660, 51 (2009) | (8) S.K. Karmee; Appl. Microbiol. Biotechnol. 81, 1013 (2009) (Review) | (9) R. Mohamed, et al.; J. Pharm. Pharmacol. 66, 769 (2014) | (10) L. Zilbermintz, et al.; Sci. Rep. 6, 34846 (2016)