Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Articaine hydrochloride
339
CHF
CHF 339.00
In stock
CDX-A0564-M500500 mgCHF 339.00
| Product Details | |
|---|---|
| Synonyms | 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride; Carticaine chlorhydrate; Carticaine hydrochloride; HOE 045; HOE 40045; Ultracaine |
| Product Type | Chemical |
| Properties | |
| Formula | C13H20N2O3S . HCl |
| MW | 284.4 . 36.5 |
| CAS | 23964-57-0 |
| RTECS | XM8511000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in water (20 mg/ml), DMSO (15mg/ml) or ethanol (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GDWDBGSWGNEMGJ-UHFFFAOYSA-N |
| Smiles | CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
Product References
(1) S.F. Malamed, et al.; J. Am. Dent. Assoc. 131, 635 (2000) | (2) G.K. Wang, et al.; J. Membr. Biol. 229, 1 (2009) | (3) M. Snoeck; Local Reg. Anesth. 5, 23 (2012) (Review)