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Chemodex
10-Acetylphenoxazine
148
CHF
CHF 148.00
In stock
CDX-A0694-M0055 mgCHF 148.00
CDX-A0694-M01010 mgCHF 238.00
CDX-A0694-M02525 mgCHF 516.00
| Product Details | |
|---|---|
| Synonyms | HJ-PI01; 1-(10H-Phenoxazin-10-yl)ethan-1-one; N-Acetylphenoxazine |
| Product Type | Chemical |
| Properties | |
| Formula | C14H11NO2 |
| MW | 225.24 |
| CAS | 6192-43-4 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white to brown powder. |
| Solubility | Soluble in DMSO (20mg/ml) or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | MXVOQCUXOQFIHU-UHFFFAOYSA-N |
| Smiles | CC(N1C2=CC=CC=C2OC3=C1C=CC=C3)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Phenoxazines are tricyclic heterocycles which have found use as therapeutic agents and scaffolds in medicinal chemistry. Due to their photophysical properties phenoxazines have been applied also as dyes in dye-sensitized solar cells and chemosensors. 10-Acetylphenoxazine be used as an intermediate and building block in organic synthesis of dyes, polymers, biochemical inhibitors or radical-trapping antioxidants. 10-Acetylphenoxazine has been described as an orally active Pim-2 inhibitor. It induces apoptosis and autophagic cell death of cancer cells in the µM range.
Product References
(1) H. Kamogawa, et al.; J. Polymer Sci. Polymer Chem. Ed. 19, 2571 (1981) | (2) V. Hernandez-Olmos, et al.; J. Med. Chem. 55, 9576 (2012) | (3) Y.-Q. Zhao, et al; Acta Pharmacol. Sin. 37, 1237 (2016) | (4) L.A. Farmer, et al.; J. Org. Chem. 82, 10523 (2017)