Chemodex

Ethyl acetimidate hydrochloride

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Specifications / Handling

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Product Details
Synonyms EAH; Ethyl acetoamidate hydrochloride; Ethyl acetocarboximidate hydrochloride; Ethyl acetoimidate hydrochloride; Ethyl ethanimidate hydrochloride; Ethyl ethanimidoate hydrochloride; Ethyl iminoacetate hydrochloride
Product Type Chemical
Properties
Formula C4H9NO . HCl
MW 123.58
CAS 2208-07-3
Source/Host Chemicals Synthetic
Purity Chemicals ≥97% (T)
Appearance White powder or crystal or chunks.
Solubility Soluble in water (50 mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key WGMHMVLZFAJNOT-UHFFFAOYSA-N
Smiles Cl.N=C(OCC)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at RT.
Documents
Product Specification Sheet
Datasheet Download PDF Download PDF

Scientific Background Information

Product Description
Ethyl acetimidate hydrochloride is a reactive amidinating reagent commonly used for the selective modification of primary amines in biomolecules. It converts amino groups (e.g., lysine residues in proteins) into amidine derivatives under mild conditions, helping preserve protein structure while altering charge properties. This reagent is widely used in protein chemistry for studying structure-function relationships, stabilizing protein interactions, and reversible chemical modification of biomolecules. Building block for synthesis.
Product-specific References
(1) K.J. Sweadner; BBRC 78, 962 (1977) | (2) M. Rack; Pflugers Arch. 404, 126 (1985) | (3) S.A. Salehi, et al.; Indian J. Ophthalmol. 40, 11 (1992) | (4) W.M. Keung, et al.; Int. J. Pept. Protein Res. 42, 504 (1993) | (5) A.J. Ganzhorn, et al.; Biochemistry 35, 10957 (1996) | (6) K. Hyodo, et al.; J. Org. Chem. 87, 2959 (2022)
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