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Chemodex
Brinzolamide
75
CHF
CHF 75.00
In stock
CDX-B0424-M01010 mgCHF 75.00
CDX-B0424-M05050 mgCHF 258.00
| Product Details | |
|---|---|
| Synonyms | (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide; AL 4862; Azopt |
| Product Type | Chemical |
| Properties | |
| Formula | C12H21N3O5S3 |
| MW | 383.51 |
| CAS | 138890-62-7 |
| RTECS | XJ9095055 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in DMSO (30mg/ml). Insoluble in water or ethanol. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HCRKCZRJWPKOAR-JTQLQIEISA-N |
| Smiles | O=S(C1=CC2=C(S1)S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.
Product References
(1) T. Stams, et al.; Protein Science 7, 556 (1998) | (2) P.A. Boriack-Sjodin, et al.; Protein Science 7, 2483 (1998) | (3) C.J. Ingram & R.F. Brubaker; Am. J. Ophthalmol. 128, 292 (1999) | (4) G.E. Barnes, et al.; Survey of Ophthalmol. 44, S131 (2012) | (5) H. Zheng & B. Lou; Acta Crystallogr. E Crystallogr. Commun. 72, 692 (2016) | (6) T. Nakano, et al.; Adv. Ther. 33, 1452 (2016) | (7) Y.R. Dong, et al.; Int. J. Ophthalmol. 11, 719 (2018)