Chemodex
5,5'-Difluoro BAPTA-AM
| Product Details | |
|---|---|
| Synonyms | 5FBAPTA-AM; 1,2-Bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester |
| Product Type | Chemical |
| Properties | |
| Formula |
C34H38F2N2O18 |
| MW | 800.66 |
| CAS | 128255-42-5 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in DMSO, DMF, EtOAc or CHCl3. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ZXXWTKAFGAXGHZ-UHFFFAOYSA-N |
| Smiles | O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=C(F)C=C1OCCOC2=CC(F)=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
5,5′-Difluoro-BAPTA-AM is a calcium chelator that may be used to modulate calcium levels and flow within cells to study calcium homeostasis and cell signaling. It is used to study cytosolic free Ca2+ by 19F-NMR. It has high selectivity for Ca2+, it is not particularly pH sensitive and is available protected as its acetoxymethyl ester. Determination with 5,5′-Difluoro-BAPTA-AM are not sensitive to cells which have a high natural background fluorescence.
(1) G.A. Smith, et al.; PNAS 80, 7178 (1983) | (2) E. Marban, et al.; Circul. Res. 66, 1255 (1990) | (3) P.E. Morris; Org. Prep. Proc. Int. 25, 445 (1993) | (4) A.R. Waldeck, et al.; Eur. Biophys. J. 27, 247 (1998)