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Chemodex
7-[(Benzyloxy)methoxy]-4-(trifluoromethyl)-2H-chromen-2-one
As low as
97
CHF
CHF 97.00
In stock
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CDX-B0733-M02525 mgCHF 97.00
CDX-B0733-M05050 mgCHF 161.00
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| Product Details | |
|---|---|
| Synonyms | BOMFC |
| Product Type | Chemical |
| Properties | |
| Formula | C18H13F3O4 |
| MW | 350.29 |
| CAS | 277309-33-8 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white to yellow solid. |
| Solubility | Soluble in chloroform or DMSO (100mM). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PNMPACFWCQYKAL-UHFFFAOYSA-N |
| Smiles | O=C1OC=2C=C(OCOCC=3C=CC=CC3)C=CC2C(=C1)C(F)(F)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BOMFC is a fluorescent probe used to study the activity of cytochrome P450 (CYP) enzymes, specifically insecticide metabolism and pyrethroid resistance. It serves as a sensitive substrate in fluorescence-based assays to assess the inhibitory action of potential synergists and to understand the interaction of pyrethroids like transfluthrin with CYP enzymes. BOMFC is a caged coumarin fluorophore that stays dark until cleaved by an enzyme. Once deprotected, it lights up blue, a classic "turn-on" fluorescent probe for enzyme activity. Once the protecting group is removed, the free hydroxycoumarin is formed. This molecule is now strongly fluorescent, Excitation: ~350-380 nm, Emission: ~450-480 nm (bright blue fluorescence).
Product References
(1) M. Nolden, et al.; Curr. Res. Parasitol. Vector Borne Dis. 1, 100041 (2021) | (2) J. Haas, et al.; Ecotoxicol. Environ. Safety 217, 112247 (2021) | (3) J. Haas, et al.; Agricult. Sci. 119, e2205850119 (2022) | (4) J. Haas, et al.; Pest Managm. Sci. 78, 965 (2022) | (5) D. Amezian, et al.; Curr. Res. Insect Sci. 2, 100037 (2022) | (6) J. Haas, et al.; Sci. Adv. 9, eadg0885 (2023) | (7) X. Xiao, et al.; Ecotoxicol. Environ. Safety 268, 115719 (2023)