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Chemodex
1-Cyano-4-dimethylaminopyridinium tetrafluoroborate
81
CHF
CHF 81.00
In stock
CDX-C0235-M100100 mgCHF 81.00
CDX-C0235-M500500 mgCHF 244.00
| Product Details | |
|---|---|
| Synonyms | CDAP |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H10N3 . BF4 |
| MW | 235.0 |
| CAS | 59016-56-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | White to yellow powder. |
| Solubility | Soluble in acetonitrile or water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ONCRRSYBEJHQMM-UHFFFAOYSA-M |
| Smiles | CN(C)C1=CC=[N+](C#N)C=C1.FB(F)F.[F] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
1-Cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP) is an organic highly effective water soluble cyanylation reagent for protein sulfhydryl groups and used to prepare protein-polysaccharide conjugates. It is employed as an activating agent for polysaccharide resins and conjugation of lipopolysaccharides while retaining endotoxic activity. The activation and further carbohydrate modification are produced under mild conditions in an aqueous solvent, an enzyme friendly environment. CDAP can be used with alkaline-sensitive polysaccharides and proteins.
Product References
(1) J. Kohn & M. Wilchek; FEBS Lett. 154, 209 (1983) | (2) A. Lees, et al.; Vaccine 14, 190 (1996) | (3) S. Bystricky, et al.; Glycoconj. J. 17, 677 (2000) | (4) F. Battaglini & D. Pallarola; Meth. Prot. Meth. Mol. Biol. 739, 161 (2011) | (5) A. Lees, et al.; Vaccines 8, 777 (2020)