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Chemodex
Caspofungin diacetate
68
CHF
CHF 68.00
In stock
CDX-C0267-M0055 mgCHF 68.00
CDX-C0267-M02525 mgCHF 272.00
| Product Details | |
|---|---|
| Synonyms | L-743,872; MK 0991 |
| Product Type | Chemical |
| Properties | |
| Formula |
C52H88N10O15 . 2C2H4O2 |
| MW | 1213.42 |
| CAS | 179463-17-3 |
| RTECS | TP8046500 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to beige powder. |
| Solubility | Soluble in DMSO (25mg/ml), DMF (20mg/ml), ehtanol (20mg/ml) or water (15mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | OGUJBRYAAJYXQP-IJFZAWIJSA-N |
| Smiles | OC(C)=O.O=C([C@H]([C@@H](CCN)O)NC([C@H]([C@@H]([C@H](C(C=C1)=CC=C1O)O)O)NC([C@H](C2)N(C[C@@H]2O)C([C@H]([C@@H](C)O)NC([C@@H](NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)C3)=O)=O)=O)=O)N4[C@@](C(N[C@@H]([C@@H]3O)NCCN)=O)([H])[C@@H](O)CC4.O=C(C)O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Caspofungin acetate is an antifungal compound that is classified as an echinocandin. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by non-competititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan and distutbing the integrity in the fungal cell wall. This agent is used in fungal cell wall biosynthesis research to study the role of β-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. It is effective against disseminated or invasive aspergillosis and candidiasis in mice.
Product References
(1) G.K. Abruzzo, et al.; Antimicrob. Agents Chemother. 41, 2333 (1997) | (2) V. Letscher-Bru, et al.; J. Antimicrob. Chemother. 51, 513 (2003) | (3) S.C. Deresinski & D.A. Stevens; Clin. Infect. Dis. 36, 1445 (2003) | (4) R. Herbrecht, et al.; J. Antimicrob. Chemother. 56, i39 (2005) | (5) M.A. Pfaller, et al.; J. Clin. Microbiol. 47, 3323 (2009) | (6) J.M. Balkovec, et al.; Nat. Prod. Rep. 31, 15 (2014)