Chemodex

Clindamycin hydrochloride

Name: Clindamycin hydrochloride
Brand: Chemodex
SKU: CDX-C0324
Price: 71.00 CHF
Availability: InStock

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CDX-C0324-G01010 gCHF 71.00

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Specifications / Handling

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Product Details
Synonyms	(7S)-7-Chloro-7-deoxylincomycin hydrochloride; NSC-756696; U21251F; Cleocin
Product Type	Chemical
Properties
Formula	C₁₈H₃₃ClN₂O₅S . HCl
MW	461.44
CAS	21462-39-5
RTECS	GF2275000
Source/Host Chemicals	Synthetic
Purity Chemicals	≥97% (TLC)
Appearance	White to off-white powder.
Solubility	Soluble in water (50mg/ml) or DMSO (50mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	AUODDLQVRAJAJM-XJQDNNTCSA-N
Smiles	O[C@H]1[C@@H](SC)O[C@]([H])([C@@H]([C@H](C)Cl)NC([C@]2([H])C[C@@H](CCC)CN2C)=O)[C@H](O)[C@@H]1O.Cl
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Clindamycin hydrochloride is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma. Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding and used to study bacterial protein synthesis.

Product-specific References

(1) M. Smieja; Can. J. Inf. Dis. Med. Microbiol. 9, 22 (1998) | (2) W.S. Champney; Curr. Drug Targets Infect. Disord. 1, 19 (2001) | (3) B. Lell & P.G. Kremsner; Antimicr. Agents Chemother. 46, 2315 (2002) | (4) J. Spizek & T. Rezanka; Appl. Microbiol. Biotech. 64, 455 (2004) | (5) J. Spizek, et al.; Adv. Appl. Microbiol. 56, 121 (2004) | (6) E.S.R. Darley & A.P. MacGowan; J. Antimicrob. Chemother. 53, 928 (2004) | (7) D.N. Wilson; Nat. Rev. Microbiol. 12, 35 (2014)

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