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Chemodex
Cyclosporin A
As low as
84
CHF
CHF 84.00
In stock
Only %1 left
CDX-C0365-M02525 mgCHF 84.00
CDX-C0365-M100100 mgCHF 245.00
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| Product Details | |
|---|---|
| Synonyms | Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A |
| Product Type | Chemical |
| Properties | |
| Formula | C62H111N11O12 |
| MW | 1202.61 |
| CAS | 59865-13-3 |
| RTECS | GZ4120000 |
| Source/Host Chemicals | Microbial |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMF (20 mg/ml), ethanol (10mg/ml) or DMSO (5 mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PMATZTZNYRCHOR-CGLBZJNRSA-N |
| Smiles | CC[C@H]1C(N(C)CC(N(C)[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@H](C)C(N(C)[C@@H](CC(C)C)C(N(C)[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H]([C@H](O)[C@@H](C/C=C/C)C)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cyclosporin A is a potent immunosuppressant. It forms a complex with cyclophilin D and inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Cyclosporin A prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation and it suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection. Cyclosporin A is an anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Cyclosporin A has been described to have antibacterial, antifungal, antiparasitic, autophagic, antiapoptotic and anticancer activity. It inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release.
Product References
(1) D.A. Fruman, et al.; PNAS 89, 3686 (1992) | (2) J. Kunz & M.N. Hall; TIBS 18, 334 (1993) | (3) B.E. Bierer, et al.; Curr. Opin. Immunol. 5, 763 (1993) | (4) D. Yocum; Br. J. Rheumatol. 32, 38 (1993) | (5) H.P. High; Tansplantation 57, 1689 (1994) | (6) S. Ho, et al.; Clin. Immunol. Immunopathol. 80, S40 (1996) | (7) K.A. Jorgensen, et al.; Scand. J. Immunol. 57, 93 (2003) | (8) S.A. Survase, et al.; Biotechnol. Adv. 29, 418 (2011)