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Chemodex
Cantharidin
122
CHF
CHF 122.00
In stock
CDX-C0643-M100100 mgCHF 122.00
CDX-C0643-M500500 mgCHF 489.00
| Product Details | |
|---|---|
| Synonyms | 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran; Cantharidine; Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione; NSC61805; BRN 0085302 |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H12O4 |
| MW | 196.2 |
| CAS | 56-25-7 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or ethanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DHZBEENLJMYSHQ-XCVPVQRUSA-N |
| Smiles | C[C@]12[C@](C(OC2=O)=O)(C)[C@@H]3CC[C@H]1O3 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.
Product References
(1) Y.M. Li & J.E. Casida; PNAS 89, 11867 (1992) | (2) Y.M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993) | (3) R.E. Honkanen, et al.; FEBS Lett. 330, 283 (1993) | (4) W. Li, et al.; Cancer Sci. 101, 1226 (2010) | (5) L.P. Deng, et al.; Curr. Med. Chem. 20, 159 (2013) (Review) | (6) A.P. Le, et al.; Oncol. Rep. 35, 2970 (2016) | (7) X. Sun, et al.; Mol. Cells 39, 869 (2016) | (8) H.C. Li, et al.; Cell Physiol. Biochem. 43, 1829 (2017) | (9) G. Wang , et al.; Curr. Med. Chem. (Epub ahead of print) (2017)
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