N-Dodecanoyl-DL-homoserine lactone

CHF 95.00
In stock
CDX-D0339-M01010 mgCHF 95.00
CDX-D0339-M05050 mgCHF 285.00
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Product Details
Synonyms C12-HSL; N-(2-Oxotetrahydro-3-furanyl)dodecanamide; N-Lauroyl-DL-homoserine lactone
Product Type Chemical
Formula C16H29NO3
MW 283.4
CAS 18627-38-8
Source/Host Chemicals Synthetic.
Purity Chemicals ≥97% (GC)
Appearance White solid.
Solubility Soluble in chloroform.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
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Product Specification Sheet
Datasheet Download PDF

N-Dodecanoyl-DL-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-κB in RAW 264.7 macrophages, increasing the expression of TNF-α, interleukin-1β (IL-1β) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It also was shown to induce cell death by apoptosis.

Product References

(1) A. Kuo, et al.; J. Bacteriol. 176, 7558 (1994) | (2) K.H. McClean, et al.; Microbiol. 143, 3703 (1997) | (3) M.K. Parsek, et al.; PNAS 143, 3703 (1997) | (4) J.K. Lithgow, et al.; Mol. Microbiol. 37, 81 (2000) | (5) G.D. Geske; JACS 127, 12762 (2005) | (6) K. Gomi, et al.; Infect. Immun. 74, 7029 (2006) | (7) S. Kristiansen, et al.; APMIS 116, 361 (2008) | (8) Y. Huang, et al.; ISME 1, (2008) | (9) L.R. Swem, et al.; Molecul. Cell 35, 143 (2009) | (10) J.T. Hodgkinson; Tetrahedron Lett. 52, 3291 (2011) | (11) D.G. Deryabina, et al.; Microbiol 82, 133 (2013)

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