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Chemodex
Dexamethasone
As low as
161
CHF
CHF 161.00
In stock
Only %1 left
CDX-D0359-M500500 mgCHF 161.00
CDX-D0359-G0011 gCHF 219.00
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| Product Details | |
|---|---|
| Synonyms | MK-125; NSC 34521; 9α-Fluoro-16α-methylprednisolone; |
| Product Type | Chemical |
| Properties | |
| Formula | C22H29FO5 |
| MW | 392.46 |
| CAS | 50-02-2 |
| RTECS | TU3980000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (25mg/ml), ethanol (20mg/ml) or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | UREBDLICKHMUKA-CXSFZGCWSA-N |
| Smiles | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Dexamethasone is a potent anti-inflammatory and immunosuppressive agent useful in a variety of inflammatory and autoimmune conditions. This synthetic glucocorticoid acts as an agonist of human glucocorticoid receptor (GR) and binds with a higher affinity than the natural ligand cortisol. Through GR activation, dexamethasone has both transactivating and transrepressing effects on gene expression, resulting in anti-inflammatory properties. The anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.
Product References
(1) M.A. Clark, et al.; Prostaglandins 32, 703 (1986) | (2) R. Matasic, et al.; J. Leukoc. Biol. 66, 909 (1999) | (3) I. Rahman; Biochem. Pharmacol. 60, 1041 (2000) | (4) I.M. Beck, et al.; Endocr. Rev. 30, 830 (2009) | (5) C. van Kooten, et al.; Handb. Exp. Pharmacol. 2009, 233 (2009) | (6) I.S. Okoye, et al.; Cancer Immunol. Immunother. (Epub ahead of print) (2020)