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Chemodex
Doramectin
As low as
116
CHF
CHF 116.00
In stock
Only %1 left
CDX-D0372-M250250 mgCHF 116.00
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| Product Details | |
|---|---|
| Synonyms | 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a; Cyclohexylavermectin B1; UK 67994; Dectomax; L701023 |
| Product Type | Chemical |
| Properties | |
| Formula | C50H74O14 |
| MW | 899.11 |
| CAS | 117704-25-3 |
| RTECS | CL1199700 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder or crystals. |
| Solubility | Soluble in DMSO (20mg/ml) or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QLFZZSKTJWDQOS-YDBLARSUSA-N |
| Smiles | C[C@H]1/C=C/C=C2CO[C@@]3([H])[C@]\2(O)[C@@](C(O[C@H]4C[C@H](O[C@@]5(C=C[C@H](C)[C@@H](C6CCCCC6)O5)C4)C/C=C(C)/[C@H]1O[C@H]7C[C@H](OC)[C@@H](O[C@H]8C[C@H](OC)[C@@H](O)[C@H](C)O8)[C@H](C)O7)=O)([H])C=C(C)[C@H]3O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Doramectin (a macrocyclic lactone derivative of ivermectin) is a broad-spectrum antiparasitic agent belonging to the avermectin class, widely used in veterinary medicine and parasitology research. It is a an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. Doramectin targets the gamma aminobutyric acid (GABA) receptors and the glutamate gated chloride ion channels (GluCl) which are concerned with neurotransmission in parasites. Opening of the chloride ion channels of the organism resulting in the influx of chloride ions causes paralysis and death. Doramectin is highly effective against a range of internal and external parasites, including gastrointestinal nematodes, mites, lice, and certain arthropods in livestock. Doramectin has also been described to have anxiolytic, anticonvulsant, anticancer, antiobesity and antiviral properties. Compound can be used as analytical reference material.
Product References
(1) C.J. Dutton, et al.; J. Antibiot. 44, 357 (1991) | (2) A.C. Goudie, et al.; Vet. Parasitol. 49, 5 (1993) | (3) N.B. Logan, et al.; Vet. Parasitol. 49, 67 (1993) | (4) N.B. Logan, et al.; Vet. Parasitol. 66, 87 (1996) | (5) H. de Souza Spinosa, et al.; Comp. Biochem. Physiol. C Toxicol. Pharmacol. 127, 359 (2000) | (6) M. Salman, et al.; Pharmaceuticals 15, 332 (2022) | (7) S. Du, et al.; Clin. Transl. Oncol. 25, 2871 (2023) | (8) Y. Zhu, et al.; Viruses 15, 1068 (2023) | (9) T. Jin, et al.; BBRC 732, 150404 (2024) | (10) M.S. Crotts, et al.; Anticancer Agents Med. Chem. 25, 244 (2025)