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Chemodex
Donepezil hydrochloride
170
CHF
CHF 170.00
In stock
CDX-D0437-M250250 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | (±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride; 2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one; E2020 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H29NO3 . HCl |
| MW | 379.5 . 36.5 |
| CAS | 120011-70-3 |
| RTECS | NK8927885 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (T) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in water (20 mg/ml). Sparingly soluble in DMSO (1mg/ml), methanol or ethanol. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
| Smiles | O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Potent non-competitive reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. Displays >1000-fold selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). It is commonly used in the treatment of Alzheimer's disease to improve cognition, memory and behavior.
Product References
(1) H. Sugimoto, et al.; J. Med. Chem. 38, 4821 (1995) | (2) E.Y. Shintani & K.M. Uchida; Am. J. Health Syst. Pharm. 54, 2805 (1997) (Review) | (3) G. Kryger, et al.; Structure 7, 297 (1999) | (4) H. Sugimoto, et al.; Curr. Med. Chem. 7, 303 (2000) (Review) | (5) D. Munoz-Torrero; Curr. Med. Chem. 15, 2433 (2008) (Review) | (6) H.M. Bryson & P. Benfield; Drugs Aging 10, 234 (1997) (Review)