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Chemodex
Doxycycline hyclate
As low as
58
CHF
CHF 58.00
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CDX-D0445-G0055 gCHF 58.00
CDX-D0445-G01010 gCHF 90.00
CDX-D0445-G02525 gCHF 180.00
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| Product Details | |
|---|---|
| Synonyms | Doxycycline hydrochloride hemiethanolate hemihydrate; α-6-Deoxy-5-hydroxytetracycline; Vibramycin hyclate |
| Product Type | Chemical |
| Properties | |
| Formula | C22H24N2O8 . HCl . 0.5H2O . 0.5C2H6O |
| MW | 512.94 |
| CAS | 24390-14-5 |
| RTECS | QI8925000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in water (5mg/ml). |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HALQELOKLVRWRI-ZVACAFRPSA-N |
| Smiles | OC1=C2C([C@H](C)C3C(C2=O)=C(O)[C@@]4(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)[C@H]3O)=CC=C1.CCO.OC5=C6C([C@H](C)C7C(C6=O)=C(O)[C@@]8(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C8=O)[C@H]7O)=CC=C5.Cl.O.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Doxycycline hyclate is a broad-spectrum tetracycline antibiotic. It binds to the 30S ribosomal subunit of bacteria and inhibits protein synthesis, preventing bacteria from growing and replicating. Next to its antibacterial activity it shows also anti-inflammatory, anti-protozoal, neuroprotective, anti-viral and anti-cancer properties. Doxycycline also inhibits selective human matrix metalloproteinases (MMP-8, MMP-9, MMP-13), inhibits replication of some viruses, inhibits the apicoplast of the malaria parasite Plasmodium spp. and reduces neuoinflammation. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Intermediate for the synthesis of fluorescent probes.
Product References
(1) G.M. Williamson; Chemotherapia 13, 1 (1968) | (2) I. Chopra; Antimicrob. Agents Chemother. 38, 637 (1994) | (3) G.N. Smith, et al.; Arthritis Rheum. 42, 1140 (1999) | (4) D.J. Gould, et al.; Gene Ther. 7, 2061 (2000) | (5) B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006) | (6) B. Berman, et al.; Drugs Today 43, 27 (2007) | (7) J. Sagar, et al.; Anticancer Agents Med. Chem. 10, 556 (2010) | (8) M.O. Griffin, et al.; Pharmacol. Res. 63, 102 (2011) | (9) A.T. Das, et al.; Curr. Gene Ther. 16, 156 (2016) | (10) C. Balducci & G. Forloni; Front. Pharmacol. 10, 738 (2019) | (11) F. Chi, et al.; Virus Res. 345, 199388 (2024)