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Chemodex
Ohira-Bestmann Reagent Solution
272
CHF
CHF 272.00
In stock
CDX-D0502-L01010 mlCHF 272.00
CDX-D0502-L05050 mlCHF 1'085.00
Product Details | |
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Synonyms | p-(1-Diazo-2-oxopropyl)-phosphonic acid, dimethyl ester; Ohira-Bestmann phosphonate; α-Azido-α-(dimethyl phosphono)acetone |
Product Type | Chemical |
Properties | |
Formula | C5H9N2O4P |
MW | 192.11 |
CAS | 90965-06-3 |
Source/Host Chemicals | Synthetic. |
Purity Chemicals | ≥96% (HPLC) |
Appearance | Liquid. |
Solubility | Soluble in acetonitrile. |
Concentration | ~10% in acetonitrile. |
Identity | Determined by 1H-NMR. |
Declaration | Manufactured by Chemodex. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
InChi Key | SQHSJJGGWYIFCD-UHFFFAOYSA-N |
Smiles | COP(=O)(OC)C(=[N+]=[N-])C(C)=O |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
Used in the Seyferth-Gilbert homologation which is a chemical reaction of an aryl ketone or aldehyde with dimethyl- or diazomethyl-phosphonate and potassium tert-butoxide to give substituted alkynes.
Product References
(1) P. Callant et al.; Synthetic Communications 14(2), 155-61(1984) | (2) S. Ohira; Synthetic Communications 19(3-4), 561-4 (1989) | (3) S. Kasteren et al.; Nature 446(7139), 1105-1109 (2007) | (4) G.J. Roth et al.; Synthesis (1), 59-62 (2004)