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Chemodex
Mitotane
As low as
54
CHF
CHF 54.00
In stock
Only %1 left
CDX-D0724-M250250 mgCHF 54.00
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| Product Details | |
|---|---|
| Synonyms | 2,4'-DDD; o,p'-DDD; 2,4'-Dichlorodiphenyl)dichloroethane; o,p'-TDE; CB 313; NSC 38721; Opeprim |
| Product Type | Chemical |
| Properties | |
| Formula | C14H10Cl4 |
| MW | 320.04 |
| CAS | 53-19-0 |
| RTECS | KH7880000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to light yellow crystalline powder. |
| Solubility | Soluble in DMF (20 mg/ml), DMSO (20 mg/ml) or ethanol (20 mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JWBOIMRXGHLCPP-UHFFFAOYSA-N |
| Smiles | C(C(Cl)Cl)(C1=C(Cl)C=CC=C1)C2=CC=C(Cl)C=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Mitotane (o,p'DDD) is an adrenocorticolytic agent primarily used in research related to adrenal gland disorders, especially adrenocortical carcinoma (ACC). Mitotane is an inhibitor of steroidogenesis and mitochondrial complex IV, also known as cytochrome c oxidase. It selectively targets adrenal cortex cells by disrupting mitochondrial function and steroidogenesis, leading to cytotoxic and endocrine-suppressive effects. Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibits enzymes involved in cortisol synthesis, such as CYP11A1 and CYP11B1, and induces adrenal atrophy. Mitotane acts through mitochondrial toxicity (induction of apoptosis), inhibition of cell proliferation in ACC, inhibition of steroidogenic enzymes, and selective adrenal cytotoxicity, making it effective in treating adrenocortical carcinoma and Cushing's syndrome. Compound can be used as analytical reference material.
Product References
(1) S. Hahner & M. Fassnacht; Curr. Opin. Investig. Drugs 6, 386 (2005) | (2) S. De Francia, et al.; Minerva Endocrinol. 37, 9 (2012) | (3) S. Hescot, et al.; Endocr. Relat. Cancer 20, 371 (2013) | (4) U. Waszut, et al.; J. Physiol. Pharmacol. 68, 13 (2017) | (5) M. Lo Iacono, et al.; Cancers 13, 5255 (2021)