Chemodex

Dienogest

CHF 61.00
In stock
CDX-D0793-M01010 mgCHF 61.00
CDX-D0793-M05050 mgCHF 244.00
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Product Details
Synonyms STS 557; BAY 86-5258; (17α)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile, 17-cyanomethyl-17-hydroxy-estra-4,9-dien-3-one; Dienogestril; Endometrion
Product Type Chemical
Properties
Formula C20H25NO2
MW 311.42
CAS 65928-58-7
RTECS RC8899500
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance White to beige powder.
Solubility Soluble in DMSO (5mg/mL clear, warming). Insoluble in water.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key AZFLJNIPTRTECV-FUMNGEBKSA-N
Smiles O=C1CCC2=C3[C@@]([C@@](CC[C@@]4(O)CC#N)([H])[C@]4(C)CC3)([H])CCC2=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Dienogest is an agonist of the progesterone receptor (PR). It is an orally active synthetic progestogen with approximately 10% of the relative affinity of progesterone. However it shows very potent progestagenic effects in the endometrium with some antiandrogenic activity and without any androgenic, glucocorticoid or mineralocorticoid effects. It has been used alone or in combination as a contraceptive and to treat uterine fibroids. Dienogest inhibits ovulation primarily through peripheral action rather than by central action on gonadotrophin secretion. Unlike other progestogens, except in the case of its strong effects in the uterus, dienogest is said to lack antiestrogenic effects, and does not antagonize the beneficial effects of estradiol, for instance in the metabolic and vascular systems. Dienogest also showed some possible antiprogestogenic activity in one animal bioassay when administered before but not at the same time as progesterone. It has shown to have anti-inflammatory activity.

Product References

(1) M. Ottel & A. Kurischko; Contraception 21, 61 (1980) | (2) R.H. Foster & M.I. Wilde; Drugs 56, 825 (1998) (Review) | (3) P.L. McCormack; Drugs 70, 2073 (2010) (Review) | (4) X. Ruan, et al.; Maturitas 71, 337 (2012) (Review) | (5) G. Grandi; Inflamm. Res. 65, 183 (2016) (Review)

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