Droperidol

Specifications / Handling

More Information
Product Details
Synonyms	1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone; NSC 169874
Product Type	Chemical
Properties
Formula	C₂₂H₂₂FN₃O₂
MW	379.43
CAS	548-73-2
RTECS	DE2100000
Purity Chemicals	≥98% (TLC)
Appearance	White to light yellow powder.
Solubility	Soluble in DMSO (20mg/ml) or DMF (20mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	RMEDXOLNCUSCGS-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(F)C=C1)CCCN2CCC(N3C4=CC=CC=C4NC3=O)=CC2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Droperidol is a butyrophenone that acts as an antagonist at dopamine receptors D2 and D4. It less potently inhibits the human voltage-gated potassium channel, 5-HT, α-adrenergic and histamine receptors. Droperidol has been shown to provide relief from acute migraines and prevent nausea and vomiting in clinical trials and has anti-psychotic activity.

Product References

(1) S.J. Peroutka & S.H. Synder; Am. J. Psychiatry 137, 1518 (1980) | (2) R. Rajamani, et al.; Bioorg. Med. chem. Lett. 15, 1737 (2005) | (3) J.R. Richards, et al.; J. Emerg. Med. 41, 389 (2011) (Review) | (4) J.D. Griffiths, et al.; Cochrane Database Syst.Rev. 9, 1 (2012) | (5) M.C. Thomas, et al.; Ann. Pharmacother. 49, 233 (2015) (Review) | (6) P. Seeman & T. Tallerico; Mol. Psych. 3, 123 (2016)

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