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Chemodex
Etoricoxib
58
CHF
CHF 58.00
In stock
CDX-E0092-M02525 mgCHF 58.00
| Product Details | |
|---|---|
| Synonyms | L-791,456; MK-0663; MK 663; 5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine; 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H15ClN2O2S |
| MW | 358.84 |
| CAS | 202409-33-4 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | MNJVRJDLRVPLFE-UHFFFAOYSA-N |
| Smiles | ClC1=CN=C(C2=CN=C(C)C=C2)C(C3=CC=C(S(C)(=O)=O)C=C3)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) and a potent cyclooxygenase-2 (COX-2) inhibitor. This dipyridinyl compound demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1 in several assays. Used to treat patients suffering from osteoarthritis and rheumatoid arthritis. Might have some chemopreventive properties.
Product References
(1) D. Riendeau, et al.; J. Pharmacol. Exper. Therap. 296, 558 (2001) | (2) P.L. McGeer, et al.; Exp. Gerontol. 37, 925 (2002) | (3) R. Chenevard, et al.; Circulation 107, 405 (2003) | (4) A. Dallob,et al.; J. Clin. Pharmacol. 43, 573 (2003) | (5) P. Patrignani, et al.; Expert Opin. Pharmacother. 4, 265 (2003) | (6) S.D. Martina, et al.; Ann. Pharmacother. 39, 854 (2005) | (7) T. Tanwar, et al.; Eur. J. Cancer Prev. 19, 280 (2010) | (8) T. Tanwar, et al.; Asian Pac. J. Cancer Prev. 11, 1329 (2010)