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Chemodex
Fluconazole
As low as
45
CHF
CHF 45.00
In stock
Only %1 left
CDX-F0104-M500500 mgCHF 45.00
CDX-F0104-G0011 gCHF 71.00
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| Product Details | |
|---|---|
| Synonyms | 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol; UK 49858; Diflucan |
| Product Type | Chemical |
| Properties | |
| Formula | C13H12F2N6O |
| MW | 306.27 |
| CAS | 86386-73-4 |
| RTECS | XZ4810000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White crystalline powder. |
| Solubility | Soluble in DMSO (10mg/ml), ethanol (10mg/ml), methanol or acetone. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| Smiles | FC1=CC(F)=C(C(CN2C=NC=N2)(O)CN3N=CN=C3)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Fluconazole is a triazole broad-spectrum antifungal agent which is effective against most Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4. Fluconazole functions by suppressing the production of ergosterol, a vital constituent of the fungal cell membrane. By impeding ergosterol synthesis, the integrity of the fungal cell membrane is compromised, ultimately resulting in fungal death. Moreover, Fluconazole hinders the activity of cytochrome P450 enzymes.
Product References
(1) M.S. Saag & W.E. Dismukes; Antimicrob. Agents Chemother. 32, 1 (1988) | (2) H. Washton; Diagn. Microbiol. Infect. Dis. 12, 229S (1989) | (3) D.W. Warnock; J. Antimicrob. Chemother. 24, 275 (1989) | (4) K. Richardson, et al.; Rev. Infect. Dis. 12, S267 (1990) | (5) S.F. Kowalsky & D.M. Dixon; Clin. Pharm. 10, 179 (1991) | (6) J.D. Morrow; Am. J. Med. Sci. 302, 129 (1991) | (7) C.M. Perry, et al.; Drugs 49, 984 (1995) | (8) M.V. Martin; J. Antimicrob. Chemother. 44, 429 (1999) | (9) N. Thamban Chandrika, et al.; Bioorg. Med. Chem. 26, 573 (2018) | (10) S. Nami, et al.; Biomed. Pharmacother. 110, 857 (2019) | (11) X. Heng, et al.; Antimicrob. Agents Chemother. 65, e02552 (2021) | (12) M.A Elzoheiry, et al.; Exp. Parasitol. 239, 108291 (2022)