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Chemodex
Fisetin
34
CHF
CHF 34.00
In stock
CDX-F0336-M100100 mgCHF 34.00
CDX-F0336-M500500 mgCHF 81.00
| Product Details | |
|---|---|
| Synonyms | 3,3',4',7-Tetrahydroxyflavone; 5-Deoxyquercetin; Natural Brown 1; CI-75620; NSC 407010; NSC 656275; BRN 0292829; Cotinin |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10O6 |
| MW | 286.24 |
| CAS | 528-48-3 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in DMSO (10mg/ml), DMF (10mg/ml) or ethanol (2mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C(OC(C3=CC(O)=C(O)C=C3)=C(O)C2=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
One of the major polyphenolic flavonoids found in various fruits and vegetables such as apples, grapes, persimmons, strawberries, cucumbers and onions. Exerts numerous beneficial biological activities, including antibacterial, antifungal, antioxidant, anti-inflammatory, antiangiogenic, antiproliferative, proapoptotic, cell cycle arrest, autophagy inducing, hypolipidemic, neuroprotective and antitumor effects. Modulates multiple signaling pathways such as blocking of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and p38, mitogen-activated protein kinases (MAPK)-dependent nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, Wnt and adrogen receptor signaling, which playing a central role in various cellular processes contributing to the malignancy. Binds to β-tubulin and disrupts microtubule dynamics. Activator of sirtuin 1 and PPARs, inhibitor of DNA topoisomerase II (topo II), inhibitor of CDK6and GSK-3beta. Recently used as fluorescent molecular probe in sodium dodecyl sulfate (SDS) induced Sol-Gel transition.
Product References
(1) M. Gabor & E. Eperjessy; Nature 212, 1273 (1966) | (2) A.J. Olaharski, et al.; Mutat. Res. 582, 79 (2005) | (3) B. Sung, et al.; Mol. Pharmacol. 71, 1703 (2007) | (4) N. Khan, et al.; Carcinogenesis 29, 1049 (2008) | (5) B.G. Szczepankiewicz & P.Y. Ng; Curr. Top. Med. Chem. 8, 1533 (2008) (Review) | (6) Y. Suh, et al.; Carcinogenesis 30, 300 (2009) | (7) Y. Suh, et al.; Carcinogenesis 31, 1424 (2010) | (8) R. Singh, et al.; J. Med. Chem. 55, 3614 (2012) | (9) V.M. Adhami, et al.; Biochem. Pharmacol. 84, 1277 (2012) (Review) | (10) D.N. Syed, et al.; Anticancer Agents Med. Chem. 13, 995 (2013) (Review) | (11) N. Khan, et al.; Antioxid. Redox Signal. 19, 151 (2013) (Review) | (12) C.H. Jung, et al.; J. Nutr. Biochem. 24, 1547 (2013) | (13) G.S. Prasath, et al.; Eur. J. Pharmacol. 740, 248 (2014) | (14) T. Jin, et al.; J. Agric. Food Chem. 62, 10468 (2014) | (15) E. Mukhtar, et al.; Cancer Lett. 367, 173 (2015) | (16) M.P. Reis, et al.; J. Appl. Microbiol. 121, 373 (2016) | (17) S.F. Nabavi, et al.; Curr. Top. Med. Chem. 16, 1910 (2016) (Review) | (18) T. Rengarajan & N.S. Yaacob; Eur. J. Pharmacol. 789, 8 (2016) (Review) | (19) M. Youns, et al.; PLoS One 12, e0169335 (2017) | (20) J. Mishra, et al.; J. Phys. Chem. B 122, 181 (2018) | (21) K D. Kashyap, et al.; Life Sci. 194, 75 (2018) (Review) | (22) K. Shanmugam, et al.; Oxid. Med. Cell Longev. 2018, 9173436 (2018)
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