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Chemodex
Limonin
54
CHF
CHF 54.00
In stock
CDX-L0280-M05050 mgCHF 54.00
| Product Details | |
|---|---|
| Synonyms | 7,16-Dioxo-7,16-dideoxylimondiol; Limonoic acid di-δ-lactone; Citrolimonin; Dictamnolactone; Evodin; Limonine; Obaculactone; NSC 36508 |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H30O8 |
| MW | 470.51 |
| CAS | 1180-71-8 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (10mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KBDSLGBFQAGHBE-MSGMIQHVSA-N |
| Smiles | O=C1[C@@]2(C)[C@@]34O[C@@H]3C(O[C@@H](C5=COC=C5)[C@]4(C)CC[C@]2([H])[C@]67[C@](C1)([H])C(C)(C)O[C@@]6([H])CC(OC7)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, anti-HIV, anti-inflammatory, antinociceptive and neuroprotective activity. Shown to inhibit arginase I and II and P-glycoprotein. May be used in assays as control, standard or competitor, or in studies on the physiology, metabolism and biosynthesis of limonin.
Product References
(1) V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980) | (2) J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982) | (3) H. Matsuda, et al.; Planta Med. 64, 339 (1998) | (4) L. Battinelli, et al.; Planta Med. 69, 910 (2003) | (5) A. Roy & S. Saraf; Biol. Pharm. Bull. 29, 191 (2006) (Review) | (6) J.S. Yoon, et al.; J. Nat. Prod. 71, 208 (2008) | (7) J.S. Yoon, et al.; Mol. Neurosci. 42, 9 (2010) | (8) M.Z. El-Readi, et al.; Eur. J. Pharmacol. 626, 139 (2010) | (9) K.N. Chidambara Murthy, et al.; J. Agric. Food Chem. 59, 2314 (2011) | (10) A. Rahman, et al.; Anticancer Agents Med. Chem. 15, 236 (2015) | (11) R. Gualdani, et al.; Molecules 21, E1530 (2016) (Review) | (12) B.H. Koo, et al.; Yonsei Med. J. 59, 366 (2018)
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