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Chemodex
7-Fluoro-2,1,3- benzoxadiazole-4-sulfonylchloride
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129
CHF
CHF 129.00
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CDX-F0577-M05050 mgCHF 129.00
CDX-F0577-M100100 mgCHF 483.00
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| Product Details | |
|---|---|
| Synonyms | CBD-F; 4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole |
| Product Type | Chemical |
| Properties | |
| Formula | C6H2ClFN2O3S |
| MW | 236.61 |
| CAS | 91366-64-2 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Light orange solid. |
| Solubility | Soluble in DMSO or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ULAADSMIEGGGMT-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(S(=O)(Cl)=O)C2=NON=C21 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole is a versatile nucleophilic intermediate or building block for the synthesis of thiol-reactive fluorogenic probes, like ADB-F, SBD-F or DBD-F. It is characterized by its unique chlorosulfonyl group that enhances electrophilic reactivity. The presence of the fluorine atom increases the compound's polarity, promoting strong dipole interactions. This compound exhibits rapid reaction kinetics, particularly in nucleophilic substitution reactions, making it an intriguing subject for exploring mechanistic pathways and reactivity profiles in synthetic chemistry.
Product References
(1) T. Toyo'oka & K. Imai; Anal. Chem. 56, 2461 (1984) | (2) T. Toyo'oka, et al.; Analyst 114, 413 (1989) | (3) T. Toyo'oka, et al.; Analyst 114, 1233 (1989) | (4) T. Kajiro, et al.; Analyst 125, 1115 (2000) | (5) K. Okabe, et al.; J. Chromatogr. A 982, 111 (2002)