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Chemodex
5-Geranyloxy-7-methoxycoumarin
81
CHF
CHF 81.00
In stock
CDX-G0228-M0011 mgCHF 81.00
| Product Details | |
|---|---|
| Synonyms | 5-G-7-MOC; 7-Methoxy-5-geranoxycoumarin |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24O4 |
| MW | 328.4 |
| CAS | 7380-39-4 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | WXUOSNJWDJOHGW-XNTDXEJSSA-N |
| Smiles | O=C1OC2=CC(OC)=CC(OC/C=C(CC/C=C(C)\C)\C)=C2C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
5-Geranyloxy-7-methoxycoumarin is a natural coumarin found in the essential oils of citrus such as bergamot, which shows antifungal, antibacterial, and anticancer activity. 5-Geranyloxy-7-methoxycoumarin arrests cells at the G0/G1 phase and induces apoptosis through activation of tumour suppressor gene p53, caspase8/3, regulation of Bcl2 and inhibition of p38 MAPK phosphorylation.
Product References
(1) M. Benincasa, et al.; Chromatographia 30, 271 (1990) | (2) S. Ben-Yehoshua, et al.; J. Agric. Food Chem. 40, 1217 (1992) | (3) Y. Miyake, et al.; J. Agric. Food Chem. 47, 3151 (1999) | (4) Y. Miyake & M. Hiramitsu; J. Food Sci. Technol. 48, 635 (2011) | (5) J.R. Patil, et al.; Planta Med. 79, 219 (2013) | (6) G.Y. Zuo, et al.; Phytomedicine 23, 1814 (2016) | (7) C. Ramirez-Pelayo, et al.; Heliyon 5, e01937 (2019) | (8) A. Maugeri, et al.; Toxins 13, 275 (2021)