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Chemodex
7-Hydroxycoumarin-3-carboxylic acid
189
CHF
CHF 189.00
In stock
CDX-H0015-M100100 mgCHF 189.00
CDX-H0015-G0011 gCHF 1'017.00
| Product Details | |
|---|---|
| Synonyms | Umbelliferone-3-carboxylic acid; HCC; NSC 115545; 7-OHCCA |
| Product Type | Chemical |
| Properties | |
| Formula | C10H6O5 |
| MW | 206.15 |
| CAS | 779-27-1 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | Beige crystalline powder. |
| Solubility | Soluble in DMF, DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | LKLWLDOUZJEHDY-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C(OC(C(C(O)=O)=C2)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
7-Hydroxycoumarin-3-carboxylic acid is one of the most popular blue fluorophores for labeling proteins and nucleic acids mostly through the in situ formation of its succinimidyl ester. It is also used to label peptides, nucleotides and carbohydrates. This coumarin is used as a fluorogenic substrate for glycosyltransferase assays and as a pH-indicator. Spectral data: Ex/Em = 386/448 nm (TRIS, pH9). Shown to have cytotoxic activity in some cancer cells.
Product References
(1) H. Offenbacher, et al.; Sens. Actuators 9, 73 (1986) | (2) H. Li, et al.; J. Cell Biol. 134, 1019 (1996) | (3) K. Higai, et al.; Biol. Pharm. Bull. 22, 333 (1999) | (4) B. Thati, et al.; Cancer Lett. 248, 321 (2007) | (5) R.W. Sabnis; Handbook of Fluorescent Dyes and Probes p246 (2015)