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Chemodex
Hyodeoxycholic acid
108
CHF
CHF 108.00
In stock
CDX-H0198-G01010 gCHF 108.00
| Product Details | |
|---|---|
| Synonyms | HDCA; 3α,6α-Dihydroxy-5β-cholan-24-oic acid; NSC 60672; BRN 3218394; Iodeoxycholic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H40O4 |
| MW | 392.57 |
| CAS | 83-49-8 |
| RTECS | FZ2050000 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (20mg/ml), DMF (30mg/ml) or ethanol (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DGABKXLVXPYZII-SIBKNCMHSA-N |
| Smiles | O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn’s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/precursor for steroid synthesis.
Product References
(1) W.Z. Chow & D.C. Huang; Sci. Sin. 14, 1083 (1965) | (2) K. Einarsson; J. Biol. Chem. 241, 534 (1966) | (3) K. Ochi, et al.; Steroids 30, 795 (1977) | (4) K.R. Bharucha; Steroids 32, 589 (1978) | (5) C.K. McSherry, et al.; Am. J. Surg. 149, 126 (1985) | (6) E. Sehayek, et al.; J. Lipid Res. 42, 1250 (2001) | (7) C. Gnewuch, et al.; World J. Gastroenterol. 15, 3134 (2009) | (8) D.M. Shih, et al.; FASEB J. 27, 3805 (2013) | (9) S. Watanabe & K. Fujita; Lipids 49, 963 (2014)