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Chemodex
Hesperidin
41
CHF
CHF 41.00
In stock
CDX-H0245-G02525 gCHF 41.00
CDX-H0245-G100100 gCHF 108.00
| Product Details | |
|---|---|
| Synonyms | Cirantin; Hesperidoside; NSC 44184; Hesperetin 7-rhamnoglucoside; Hesperitin-7-rutinoside; Diosmin EP Impurity B |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H34O15 |
| MW | 610.56 |
| CAS | 520-26-3 |
| RTECS | MK6650000 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Beige to light brown powder. |
| Solubility | Soluble in DMSO (5mg/ml), DMF (3mg/ml) or pyridine (50mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QUQPHWDTPGMPEX-QJBIFVCTSA-N |
| Smiles | O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=CC(O)=C31 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin, which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability. Both hesperidin (Hsd) and its aglycone hesperetin (Hst) have various biological properties. Studies have shown both anti-cancer and cancer chemopreventive effects, associated with their antioxidant, radical scavenging and anti-inflammatory activities. In addition, Hsd and Hst interfere at different stages of cancer. They inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, Bcl-2 and Bax for the induction of apoptosis, and COX-2, MMP-2 and MMP-9 for the inhibition of angiogenesis and metastasis. They also have show cardioprotective, neuroprotective and antimicrobial effects.
- Antiviral, potential inhibitor against SARS-CoV-2 infection.
Product References
(1) E. Meiyanto, et al.; Asian Pac. J. Cancer Prev. 13, 427 (2012) | (2) H. Parhiz, et al.; Phytother. Res. 29, 323 (2015) (Review) | (3) A. Roohbakhsh, et al.; Life Sci. 124, 64 (2015) (Review) | (4) M. Iranshahi, et al.; Life Sci. 137, 125 (2015) (Review) | (5) A. Ahmadi & A. Shadboorestan; Nutr. Cancer 68, 29 (2016) (Review) | (6) A. Ahmadi, et al.; Curr. Med. Chem. 22, 3462 (2015) (Review) | (7) S. Tejada, et al.; Curr. Med. Chem. 25, 4929 (2018) (Review) | (8) M. Hajialyani, et al.; Molecules 24, E648 (2019) (Review)
- Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection: F.J. Cheng, et al.; Nutrients 13, 2800 (2021)
- Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2: A. Hijikata, et al.; FEBS Open Bio. 12, 285 (2022)