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Chemodex
1α-Hydroxyvitamin D3
As low as
155
CHF
CHF 155.00
In stock
Only %1 left
CDX-H0262-M0055 mgCHF 155.00
CDX-H0262-M01010 mgCHF 251.00
CDX-H0262-M02525 mgCHF 451.00
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| Product Details | |
|---|---|
| Synonyms | 1α-Hydroxycholecalciferol; Alfacalcidol; α-Calcidol; Etalpha; 1-hydroxy Cholecalciferol; Tevabone; Alpha D3; 1&alpha,-OH-D3 |
| Product Type | Chemical |
| Properties | |
| Formula | C27H44O2 |
| MW | 400.64 |
| CAS | 41294-56-8 |
| Source/Host Chemicals | Semisynthetic |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMF (20 mg/ml), DMSO (20 mg/ml), ethanol (20 mg/ml). |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | OFHCOWSQAMBJIW-AVJTYSNKSA-N |
| Smiles | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
1α-Hydroxyvitamin D3 is a synthetic analog of vitamin D used extensively in biomedical research and clinical studies for its potent calcium-regulating properties. Ths prodrug is rapidly converted by cytochrome P450 isoforms in the liver to the active metabolite 1α,25-dihydroxyvitamin D3, bypassing the need for renal 1α-hydroxylation. This makes it particularly valuable in studying calcium and phosphate homeostasis, bone metabolism, and the treatment of disorders like osteoporosis and chronic kidney disease-related mineral and bone disorder (CKD-MBD). 1α-Hydroxyvitamin D3 is a non-selective VDR activator and used to explore vitamin D receptor (VDR) signaling, immune modulation, and potential anti-inflammatory and anti-proliferative effects across various cell types. Compound can be used as analytical reference material.
Product References
(1) J.E. Zerwekh, et al.; Biochem. 13, 4097 (1974) | (2) N. Takeshita, et al.; Life Sci. 56, 1095 (1995) | (3) A. Shiraishi, et al.; Calcif. Tissue Int. 65, 311 (1999) | (4) R.A. Upton, et al.; Nephrol. Dial. Transplant 18, 750 (2003) | (5) R. Nuti, et al.; Rheumatol. Int. 26, 445 (2006) | (6) R.C. Tuckey, et al.; J. Steroid Biochem. Mol. Biol. 112, 213 (2008) | (7) N. Kubodera; Molecules 14, 3869 (2009) | (8) C.S. Ritter & A.J. Brown; J. Mol. Endocrinol. 46, 63 (2011) | (9) T. Suda, et al.; Arch. Biochem. Biophys. 523, 22 (2012)